Hidradenitis suppurativa

BAD Patient Information: Hidradenitis suppurativa PCDS: Hidradenitis suppurativa DermNet: Hidradenitis suppurativa

Treatment of hidradenitis suppurativa – mild disease

Mild disease – Intermittent small numbers of inflammatory nodules and/or abscesses. Minimal scarring and no tunnels.


Clindamycin
Clindamycin 1% aqueous lotion

Doxycycline (or lymecycline if intolerant of doxycycline) for three months.

Doxycycline
Doxycycline 100mg capsules
Lymecycline
Lymecycline 408mg capsules

Prescribing Notes:

  • Manage mild disease in primary care initially and consider referral if poor response to treatment.
  • Provide BAD patient information leaflet.
  • Antiseptic washes (e.g. chlorhexidine) may also be used.

History Notes

28/07/2026

Hidradenitis suppurativa section added to Skin formulary chapter (WoS FC 23/06/2026).

Treatment of hidradenitis suppurativa – moderate to severe disease

Moderate to severe disease – more frequent or constant nodules and/or abscesses with scarring +/- tunnels.


Refer to Dermatology. This pathway provides treatment options while awaiting secondary care review.

Clindamycin
Clindamycin 1% aqueous lotion

Doxycycline (or lymecycline if intolerant of doxycycline) for three months.

Doxycycline
Doxycycline 100mg capsules
Lymecycline
Lymecycline 408mg capsules

If previous treatment ineffective, consider replacing with oral clindamycin and rifampicin for 3 months while awaiting Dermatology review.


Clindamycin
Clindamycin 300mg capsules
Rifampicin
Rifampicin 300mg capsules

Additional options that may be considered in addition to previous treatments.


Metformin
Metformin 500mg modified-release tablets
Metformin 1g modified-release tablets

For females if having cyclical flares.

Spironolactone
Spironolactone 50mg tablets
Spironolactone 100mg tablets

Prescribing Notes:

  • For moderate to severe disease, please refer to Dermatology and commence initial management as outlined.
  • Provide BAD patient information leaflet.
  • Antiseptic washes (e.g. chlorhexidine) may also be used.

History Notes

28/07/2026

Hidradenitis suppurativa section added to Skin formulary chapter (WoS FC 23/06/2026).

Treatment of hidradenitis suppurativa – acute flares regardless of disease severity

Acute flares (e.g. acutely inflamed abscess) regardless of disease severity.


Co-amoxiclav
Co-amoxiclav 500mg/125mg tablets

If penicillin allergic, consider clarithromycin or co-trimoxazole.

Clarithromycin
Clarithromycin 500mg tablets
Co-trimoxazole
Co-trimoxazole 80mg/400mg tablets
Triamcinolone acetonide
Triamcinolone acetonide 10mg/1ml suspension for injection ampoules

History Notes

28/07/2026

Hidradenitis suppurativa section added to Skin formulary chapter (WoS FC 23/06/2026).

Treatment of hidradenitis suppurativa not responding to conventional therapy

Anti-TNF – adalimumab. Adalimumab should be prescribed by brand name in line with local guidance (where available).

Adalimumab
Amgevita HCF 40mg/0.4ml solution for injection pre-filled syringes
Amgevita HCF 40mg/0.4ml solution for injection pre-filled pens
Amgevita HCF 80mg/0.8ml solution for injection pre-filled syringes
Amgevita HCF 80mg/0.8ml solution for injection pre-filled pens
Yuflyma 40mg/0.4ml solution for injection pre-filled pens
Yuflyma 80mg/0.8ml solution for injection pre-filled pens

IL-17A inhibitor – secukinumab.

Secukinumab
Cosentyx 150mg/1ml solution for injection pre-filled syringes
Cosentyx 150mg/1ml solution for injection pre-filled pens
Cosentyx 300mg/2ml solution for injection pre-filled pens

IL-17A and IL-17F inhibitor – bimekizumab.

Bimekizumab
Bimzelx 160mg/1ml solution for injection pre-filled syringes
Bimzelx 160mg/1ml solution for injection pre-filled pens
Bimzelx 320mg/2ml solution for injection pre-filled syringes
Bimzelx 320mg/2ml solution for injection pre-filled pens

Anti-TNF – infliximab.

Infliximab
Remsima 120mg/1ml solution for injection pre-filled pens
Remsima 100mg powder for concentrate for solution for infusion vials

History Notes

28/07/2026

Hidradenitis suppurativa section added to Skin formulary chapter (WoS FC 23/06/2026).

Treatment of moderate to severe Hidradenitis suppurativa not responding to conventional therapy

Anti-TNF – adalimumab. Adalimumab should be prescribed by brand name in line with local guidance (where available).

Adalimumab
Amgevita HCF 40mg/0.4ml solution for injection pre-filled syringes
Amgevita HCF 40mg/0.4ml solution for injection pre-filled pens
Amgevita HCF 80mg/0.8ml solution for injection pre-filled syringes
Amgevita HCF 80mg/0.8ml solution for injection pre-filled pens
Yuflyma 40mg/0.4ml solution for injection pre-filled pens
Yuflyma 80mg/0.8ml solution for injection pre-filled pens

Prescribing Notes:

  • Adalimumab is indicated for the treatment of active moderate to severe hidradenitis suppuritiva (HS) (acne inversa) in adults and adolescents from 12 years with an inadequate response to conventional systemic HS therapy.

History Notes

28/07/2026

Hidradenitis suppurativa section added to Skin formulary chapter (WoS FC 23/06/2026).