Pertussis

The regional formulary will not cover all eventualities for infections medicines choices. As with any condition; patient specific factors and sensitivities need to be considered. Please consider this regional formulary advice alongside any relevant local Board guidelines.

NICE CKS: Whooping cough UK Health Security Agency: Pertussis

Treatment of pertussis

If onset of cough is within the previous 14 days.

Clarithromycin
Clarithromycin 500mg tablets

500mg twice a day for 7 days.

Preferred option in pregnancy.

Erythromycin
Erythromycin 250mg gastro-resistant tablets

500mg every 6 hours for 7 days, doses can be doubled in severe infections.

Prescribing Notes:

  • Public Health should be notified to assess and arrange antibiotic prophylaxis and vaccination, where indicated in line with national guidance.
  • For further information including advice on vaccination of the index case and close contacts refer to UK Health Security Agency guidance.

History Notes

30/07/2026

Regional formulary chapter launched.

Prophylaxis of pertussis

Public Health should always be contacted in the first instance.

Clarithromycin
Clarithromycin 500mg tablets

500mg twice a day for 7 days.

Preferred option in pregnancy.

Erythromycin
Erythromycin 250mg gastro-resistant tablets

500mg every 6 hours for 7 days, doses can be doubled in severe infections.

Prescribing Notes:

  • Public Health should be notified to assess and arrange antibiotic prophylaxis and vaccination, where indicated in line with national guidance.
  • For further information including advice on vaccination of the index case and close contacts refer to UK Health Security Agency guidance.

History Notes

30/07/2026

Regional formulary chapter launched.