Prostatitis

The regional formulary will not cover all eventualities for infections medicines choices. As with any condition; patient specific factors and sensitivities need to be considered. Please consider this regional formulary advice alongside any relevant local Board guidelines.

NICE NG110: Prostatitis (acute)

Treatment of acute prostatitis

Send urine for culture. Consider important safety issues and potentially long-lasting side-effects prior to prescribing (see prescribing notes).

Co-trimoxazole
Co-trimoxazole 80mg/400mg tablets

960mg twice day for 14 days then review.

Only if urine culture shows sensitivity.

Ciprofloxacin
Ciprofloxacin 250mg tablets

500mg every 12 hours for 14 days. Reassess at 14 days.

Prescribing Notes:

  • Refer to BNF important safety information for all quinolones prior to prescribing.
  • See MHRA Drug Safety Update (January 2024): Fluoroquinolones must only be used in situations when other antibiotics, that are commonly recommended for the infection, are inappropriate such as:
    • there is resistance to other first-line antibiotics recommended for the infection
    • other first-line antibiotics are contraindicated in an individual patient
    • other first-line antibiotics have caused side effects in the patient requiring treatment to be stopped
    • treatment with other first-line antibiotics has failed
  • Send MSU for culture and start treatment.
  • Advise paracetamol (+/- low-dose weak opioid) for pain, or ibuprofen if preferred and suitable.
  • Review antibiotic treatment after 14 days and either stop antibiotics or continue for a further 14 days if needed (based on assessment of history, symptoms, clinical examination, urine and blood tests).
  • Intravenous antibiotics may be indicated if unable to take oral antibiotics or severely unwell, refer to NICE guideline above.
  • With any genital symptoms consider a sexually transmitted infection (STI) test including chlamydia, gonorrhoea, HIV and syphilis.
  • Co-trimoxazole 80mg/400mg tablets are more cost-effective dose for dose than 160mg/800mg tablets.
  • Ciprofloxacin 250mg tablets are more cost-effective dose for dose than 500mg tablets.

History Notes

30/07/2026

Regional formulary chapter launched.